Document Detail

Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats.
MedLine Citation:
PMID:  9519808     Owner:  NLM     Status:  MEDLINE    
The effect of gamma-glutamylmethylamide(GMA), one of the components of green tea extract, on the blood pressure in spontaneously hypertensive rats (SHR) was investigated. The effect of glutamic acid and r-glutamylethylamide (theanine), which is structurally similar to GMA, was also examined. When SHR were injected with glutamic acid (2000mg/kg), the blood pressure was not altered. The same dose of theanine decreased it significantly. GMA administration to SHR reduced the blood pressure significantly, and its degree of hypotensive action was more effective than that by theanine administration.
H Yokogoshi; M Kobayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  62     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1998  
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1065-8     Citation Subset:  IM    
Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, University of Shizuoka, Yada, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Glutamates / pharmacology*
Glutamic Acid / pharmacology
Hypertension / drug therapy*
Rats, Inbred SHR
Reg. No./Substance:
0/Antihypertensive Agents; 0/Glutamates; 0/Tea; 3081-61-6/theanine; 3081-62-7/gamma-glutamylmethylamide; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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