Document Detail

Hypotensive drugs and the cellular energetic potential.
MedLine Citation:
PMID:  1461173     Owner:  NLM     Status:  MEDLINE    
Clinical and experimental investigations have revealed changes of the Na, K, Ca and Mg concentration in serum and cells in patients with essential arterial hypertension (EAH). Some hypotensive drugs correct, more or less, the electrolytic abnormalities at the same time as the decrease of arterial pressure. Epidemiological studies have shown a lower arterial blood pressure in populations with decreased intake of Na and an increased intake of K, Ca and Mg. However the most frequently encountered electrolyte anomaly in patients with EAH is hypophosphatemia, mainly induced by a shift of inorganic phosphate from serum into the cells. Probably the increased influx of inorganic phosphate from the serum, increases the arterial cellular energetic potential. As hypotensive drugs lead to a reduction of the inorganic phosphate shift from serum into the cells one may suggest that the obtained decrease of arterial blood pressure may be at least partially due to a diminished energetic potential of certain cells.
G Uza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  39     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-01-12     Completed Date:  1993-01-12     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  130-2     Citation Subset:  IM    
I Medical Clinic, Cluj-Napoca, Romania.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Clonidine / pharmacology
Hypertension / drug therapy,  metabolism
Nifedipine / pharmacology
Phosphates / blood
Propranolol / pharmacology
Water-Electrolyte Balance / drug effects*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Phosphates; 21829-25-4/Nifedipine; 4205-90-7/Clonidine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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