| Hypotensive and Heart Rate-Lowering Effects of Low-Dose Bisoprolol Determined Based on Self-Measured Blood Pressure at Home. | |
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MedLine Citation:
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PMID: 22571411 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR. |
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Authors:
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Michihiro Satoh; Taku Obara; Urara Ikeda; Yuka Kobayashi; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-9 |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: - ISSN: 1525-6006 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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