Document Detail


Hypotension and reduced catecholamines in neuropeptide Y transgenic rats.
MedLine Citation:
PMID:  12668588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neurons that control blood pressure express neuropeptide Y. Administered centrally, this neuropeptide reduces blood pressure and anxiety, together with lowering sympathetic outflow. The generation of neuropeptide Y transgenic rats overexpressing this peptide, under its natural promoter, has allowed us to examine the role of endogenous neuropeptide Y in the long-term control of blood pressure by the sympathetic nervous system. This study tested a hypothesis that endogenous neuropeptide Y acts to reduce blood pressure and catecholamine release. Blood pressure was measured by radiotelemetry in conscious male transgenic and nontransgenic littermates (control). Novel cage with cold water and forced swimming were used as stressors. Catecholamines were determined in 24-hour urine (baseline) and plasma (cold water stress) by a radioenzymatic assay. Blood pressures in baseline and during the stresses were significantly reduced in the transgenic rats. The lower blood pressure was associated with reduced catecholamines, lower decrease in pressure after autonomic ganglionic blockade, and increased longevity. Data obtained through the use of this transgenic rat model support and extend the evidence for the previously postulated sympatholytic and hypotensive effects of neuropeptide Y and provide novel evidence for an important physiological role of endogenous peptide in blood pressure regulation. As indicated by the increased longevity of these rats, in long-term regulation, these buffering actions of neuropeptide Y may have important cardiovascular protective effects against sympathetic hyperexcitation.
Authors:
Mieczyslaw Michalkiewicz; Kriss M Knestaut; Elena Yu Bytchkova; Teresa Michalkiewicz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-03-31
Journal Detail:
Title:  Hypertension     Volume:  41     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-05     Completed Date:  2003-06-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1056-62     Citation Subset:  IM    
Affiliation:
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226-050, USA. mmichalk@mcw.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Blood Pressure / physiology
Brain / metabolism
Catecholamines / blood*,  metabolism,  urine
Female
Genotype
Heart Rate / physiology
Hypotension / physiopathology*
Male
Neuropeptide Y / genetics,  physiology*
Rats
Rats, Sprague-Dawley
Stress, Physiological / physiopathology
Survival Analysis
Swimming
Grant Support
ID/Acronym/Agency:
HL-57921/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Neuropeptide Y
Comments/Corrections
Comment In:
Hypertension. 2003 Nov;42(5):e13-4; author reply e13-4   [PMID:  14504258 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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