Document Detail

Hypotension and bradycardia in infants after the use of topical brimonidine and beta-blockers.
MedLine Citation:
PMID:  12690374     Owner:  NLM     Status:  MEDLINE    
Brimonidine is a selective alpha-2 adrenergic agonist used to treat glaucoma. There have been several reports of central nervous system depression after its use in infants. We observed rapid-onset bradycardia and decreased blood pressure in addition to central nervous system depression in 2 infants who received concomitant topical brimonidine and beta-blockers.
Nils K Mungan; Thomas W Wilson; Ken K Nischal; Gideon Koren; Alex V Levin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus     Volume:  7     ISSN:  1091-8531     ISO Abbreviation:  J AAPOS     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-10-29     Revised Date:  2006-04-21    
Medline Journal Info:
Nlm Unique ID:  9710011     Medline TA:  J AAPOS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-70     Citation Subset:  IM    
Department of Ophthalmology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
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MeSH Terms
Administration, Topical
Adrenergic alpha-Agonists / administration & dosage*,  adverse effects*
Adrenergic beta-Antagonists / administration & dosage*,  adverse effects*
Bradycardia / chemically induced*
Glaucoma / drug therapy*,  physiopathology
Hypotension / chemically induced*
Infant, Newborn
Intraocular Pressure / drug effects
Quinoxalines / administration & dosage*,  adverse effects*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Antagonists; 0/Quinoxalines; 59803-98-4/brimonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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