Document Detail

Hypotension as a Risk Factor for Acute Kidney Injury in ICU Patients.
MedLine Citation:
PMID:  22158679     Owner:  NLM     Status:  Publisher    
In the context of critical illness, hypotension may be associated with acute kidney injury (AKI). Using the MIMIC II database, we studied the risk of AKI in ICU patients as a function of both the severity and duration of hypotension. Multivariate logistical regression was performed to find correlations between hypotension and AKI. Minimum mean arterial blood pressure (MAP) and the amount of time MAP was below a range of hypotension thresholds in a target 48-hour window (prior to AKI onset) were used as primary predictive variables in the multivariate model. Our results indicate that the risk of AKI was related to the severity of hypotension with an odds ratio (OR) of 1.03, 95% CI 1.02-1.04 (p < 0.0001) per 1 mmHg decrease in minimum MAP ≥ 80 mmHg. For each additional hour MAP was less than 70, 60, 50 mmHg, the risk of AKI increased by 2% (OR 1.02, 95% CI 1.00-1.03, p = 0.0034), 5% (OR 1.05, 95% CI 1.02-1.08, p = 0.0028), and 22% (OR 1.22, 95% CI 1.04-1.43, p = 0.0122) respectively.
Li-Wei Lehman; Mohammed Saeed; George Moody; Roger Mark
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Publication Detail:
Journal Detail:
Title:  Computing in cardiology     Volume:  37     ISSN:  -     ISO Abbreviation:  -     Publication Date:  2010  
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101562329     Medline TA:  Comput Cardiol (2010)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1095-1098     Citation Subset:  -    
Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.
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Grant Support
R01 EB001659-08//NIBIB NIH HHS

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