| Hypospadias in infancy I) pathophysiologic considerations II) hormonal balance studies (author's transl) | |
| | |
MedLine Citation:
|
PMID: 129752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Animal studies (Goldman, Jost) and test results in patients with hypospadias (Bongiovanni, Zachmann, Knorr) put up the question, whether all forms of hypospadias could be caused by a disturbance or peculiarity of the adrenal or gonadal androgen metabolism. Healthy volunteers and boys with glandal, penile and scrotal hypospadias were examined for their basal hormon status and response to stimulation. The following test-results are uniform, however due to the small number of cases, we would like to use these data more as a suggestion for peculiarities of the androgen metabolism, these are: 1. signs of quantitatively decreased testosteron production. 2. signs of qualitatively deranged testosteron-biosynthesis in patients with hypospadias due to a) decrease in certain enzymes in the testosteron-biosyntheticpathway (3-beta-hydroxysteroid-dehydrogenase, 17,20-desmolase, 17-beta-hydroxysteroid oxidoreductase) b) increased peripheral conversion of androgen metabolites 3. signs of a suggested "saving" of androgens in the catabolism of those compounds and, last not least 4. signs of gonadal transformation of the adrenals, seen by increased adrenal androgen production and an adrenal transformation of the gonads, which can ultimately be considered as faulty differentiation of these 2 organ systems. |
| | |
Authors:
|
J Glatzl |
Publication Detail:
|
Type: English Abstract; Journal Article |
Journal Detail:
|
Title: Pädiatrie und Pädologie Volume: 10 ISSN: 0030-9338 ISO Abbreviation: Padiatr Padol Publication Date: 1975 |
Date Detail:
|
Created Date: 1976-04-30 Completed Date: 1976-04-30 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0022370 Medline TA: Padiatr Padol Country: AUSTRIA |
Other Details:
|
Languages: ger Pagination: 420-61 Citation Subset: IM |
Vernacular Title:
|
Hypospadie im Kindesalter. I. Pathogenetische Uberlegungen II. Hormonelle Untersuchungen |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Androgens
/
metabolism Androsterone / urine Dehydroepiandrosterone / urine Female Genitalia / anatomy & histology, physiopathology Humans Hydroxysteroids / deficiency Hypospadias* / etiology, metabolism Infant Lyases / deficiency Male Pregnanediol / urine Pregnanetriol / urine Steroids / metabolism Testosterone / deficiency, urine Ureter / anatomy & histology, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Androgens; 0/Hydroxysteroids; 0/Steroids; 26445-07-8/Pregnanediol; 27178-64-9/Pregnanetriol; 53-41-8/Androsterone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; EC 4.-/Lyases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ovarian and peripheral venous steroids in XY gonadal dysgenesis and gonadoblastoma.
Next Document: Structural change of special education in rural districts (author's transl)