Document Detail

Hyposmotically-activated efflux of L-carnitine from a human mammary cancer cell line.
MedLine Citation:
PMID:  12166827     Owner:  NLM     Status:  MEDLINE    
Cell-swelling, induced by a hyposmotic challenge, stimulated the efflux of L-carnitine from a human mammary cancer cell line, MDA-MB-231. The response was dependent upon the extent of the osmotic shock. Hyposmotically-activated L-carnitine efflux was inhibited by the anion transport blocker diiodosalicylate. The efflux of taurine from MDA-MB-231 cells was also stimulated by a hyposmotic shock via a pathway sensitive to diiodosalicylate. L-carnitine efflux from MDA-MB-231 cells was stimulated by isosmotic swelling in a manner which was inhibited by diiodosalicylate. The results suggest that L-carnitine may exit cells via a volume-sensitive pathway: it is possible that L-carnitine efflux may utilize the same pathway as amino acids. The efflux of L-carnitine via this route could have a major effect on the intracellular concentration of L-carnitine and could facilitate transepithelial L-carnitine transport.
D B Shennan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience reports     Volume:  21     ISSN:  0144-8463     ISO Abbreviation:  Biosci. Rep.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-08-08     Completed Date:  2002-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102797     Medline TA:  Biosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-87     Citation Subset:  IM    
Hannah Research Institute, Ayr.
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MeSH Terms
Biological Transport
Breast Neoplasms / metabolism*
Carnitine / metabolism*
Osmolar Concentration
Salicylates / metabolism
Sodium / metabolism
Taurine / metabolism
Tumor Cells, Cultured
Reg. No./Substance:
0/Salicylates; 107-35-7/Taurine; 541-15-1/Carnitine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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