Document Detail

Hypoplastic right-heart syndrome presenting as multiple miscarriages.
MedLine Citation:
PMID:  22740745     Owner:  NLM     Status:  MEDLINE    
Reversible causes of miscarriage are many, but they affect only 1% of women who are trying to conceive. Herein, we describe the case of a 23-year-old woman who presented for evaluation of repeated miscarriages and was found to have hypoxemia and erythrocytosis. Further evaluation revealed hypoplastic right-heart syndrome with an intracardiac shunt. She underwent hybrid repair with pulmonary valve balloon valvuloplasty, followed by surgery to perform atrial septal defect closure and a Glenn anastomosis. The erythrocytosis and hypoxemia resolved, and she was able to conceive and deliver a healthy baby at term 2 years later. This is a unique case of a rare congenital heart defect that went unnoticed until adulthood, when attempts at pregnancy failed because of the associated hypoxemia. Timely and appropriate treatment led to a successful pregnancy after repeated miscarriages. This case exemplifies the need for a comprehensive medical evaluation of every woman with a history of multiple miscarriages to determine whether a reversible cause exists.
Chadi Dib; Philip A Araoz; Norman P Davies; Joseph A Dearani; Naser M Ammash
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  39     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-28     Completed Date:  2012-11-19     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-54     Citation Subset:  IM    
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Abnormalities, Multiple*
Abortion, Habitual / etiology*
Anoxia / etiology
Balloon Valvuloplasty
Cardiac Catheterization
Cardiac Surgical Procedures
Echocardiography, Doppler, Color
Heart Defects, Congenital / complications,  diagnosis*,  physiopathology,  therapy
Heart Septal Defects, Atrial / complications,  diagnosis
Heart Ventricles / abnormalities*,  physiopathology
Live Birth
Magnetic Resonance Imaging
Polycythemia / etiology
Pregnancy Complications, Cardiovascular / diagnosis*,  physiopathology,  therapy
Pulmonary Valve Stenosis / complications,  diagnosis
Treatment Outcome
Tricuspid Valve / abnormalities
Young Adult

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