Document Detail

Hypoplasia and immaturity of the terminal lung unit (acinus) in congenital diaphragmatic hernia.
MedLine Citation:
PMID:  3662245     Owner:  NLM     Status:  MEDLINE    
We assessed the maturity of the lungs and the radial count in 10 infants with congenital diaphragmatic hernia who died in the immediate perinatal period. The lungs were all immature, with a histologic appearance of less than stated gestational age. The ipsilateral lungs were less mature in appearance than were the contralateral ones. The radial count, an assessment of acinar complexity, was reduced in all cases, and once again the ipsilateral lung was more affected. We present evidence that, in 4 of 6 lungs, volumes were more reduced than predicted from the radial count, and this may be due to loss of (airway) units. We have discussed the controversy about the appearance of the acinus in diaphragmatic hernia and present reasons to explain this. Hyaline membrane disease often occurs in diaphragmatic hernia, even at full term. Intra-alveolar hemorrhage is a common complication of diaphragmatic hernia.
D K George; T P Cooney; B K Chiu; W M Thurlbeck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  136     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-06     Completed Date:  1987-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  947-50     Citation Subset:  AIM; IM    
Department of Pathology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Body Weight
Fetal Organ Maturity
Gestational Age
Hernia, Diaphragmatic / congenital*,  pathology
Infant, Newborn
Lung / abnormalities*
Organ Size
Pulmonary Alveoli / pathology

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