Document Detail

Hypopituitarism following brain injury: when does it occur and how best to test?
MedLine Citation:
PMID:  20526744     Owner:  NLM     Status:  In-Data-Review    
Aim of this review is to highlight how and when Traumatic Brain Injury (TBI) as well as Subarachnoid Haemorrhage (SAH) and primary Brain Tumours (pBT) of the Central Nervous System (CNS) can induce hypopituitarism, an under-diagnosed clinical problem. Moreover, this review aims to clarify, on the basis of the recent evidences, how these patients have to be tested for pituitary-function. Both retrospective and prospective studies recommended that patients with more severe form of Brain Injuries (BI) and in particular, those with fractures of the base of the skull or early diabetes insipidus, have to be closely monitored for signs and symptoms of endocrine dysfunction. Further studies will be crucial to raise awareness and remind physicians on the prevalence of hypopituitarism in patients with BI and to elucidate any incremental benefits these patients may receive from hormone replacement.
Valentina Gasco; Flavia Prodam; Loredana Pagano; Silvia Grottoli; Sara Belcastro; Paolo Marzullo; Guglielmo Beccuti; Ezio Ghigo; Gianluca Aimaretti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pituitary     Volume:  15     ISSN:  1573-7403     ISO Abbreviation:  Pituitary     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Dogliotti 14, 10126, Turin, Italy,
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