Document Detail

Hypopituitarism and antiphospholipid syndrome.
MedLine Citation:
PMID:  9586417     Owner:  NLM     Status:  MEDLINE    
Vascular damage is a well known cause of hypopituitarism since Sheehan's report of postpartum pituitary necrosis; it has subsequently been reported that also sickle-cell anemia, eclampsia, pituitary apoplexy and other pathologies may induce failure of the anterior hypophysis through this mechanism. The antiphospholipid syndrome (APS) is characterized by widespread arterial and venous thrombosis with resulting different clinical features; Addison's disease due to adrenal thrombosis is the only endocrine involvement reported so far in this syndrome. We report here a case of global anterior pituitary insufficiency which developed soon after cerebral ischaemic stroke in a 62 year aged woman with Lupus aicoagulant activity (LAC) and large atrial thrombosis; underlying pathologies were excluded by appropriate investigations. Therefore in our opinion this is the first case in which anterior hypopituitarism is reported in the clinical constellation of APS and the second type of endocline involvement.
C Pandolfi; A Gianini; V Fregoni; G Nalli; L Faggi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Minerva endocrinologica     Volume:  22     ISSN:  0391-1977     ISO Abbreviation:  Minerva Endocrinol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-06-12     Completed Date:  1998-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8406505     Medline TA:  Minerva Endocrinol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  IM    
Dipartimento di Endocrinologia, Ospedale Maggiore, Lodi.
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MeSH Terms
Antiphospholipid Syndrome / etiology*,  metabolism,  pathology
Hypopituitarism / complications*,  metabolism,  pathology
Lupus Coagulation Inhibitor / metabolism
Middle Aged
Reg. No./Substance:
0/Lupus Coagulation Inhibitor

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