Document Detail

Hypopigmented mycosis fungoides: case reports and literature review.
MedLine Citation:
PMID:  11003719     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hypopigmented mycosis fungoides is a rare variant of mycosis fungoides (MF) that usually has a predilection for young individuals with dark complexion. OBJECTIVE: The aim is to describe new cases of hypopigmented MF with confirmed T-cell receptor gene rearrangement analysis. METHODS: This article includes case reports and a literature review. RESULTS: Three out of four hypopigmented MF patients had a positive TCR gene rearrangement. A fifth patient is reported who had hypopigmented mycosis fungoides and classical Pautrier microabscesses, for whom no TCR gene rearrangement analysis was performed. CONCLUSION: Although hypopigmented MF has a predilection for dark-complexioned populations, it can also affect Caucasian patients. In challenging cases, polymerase chain reaction can be a useful method for detecting early cases of hypopigmented MF.
M S Qari; N Li; M F Demierre
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  4     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2000-10-31     Revised Date:  2007-07-04    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
The Skin Oncology Program, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.
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MeSH Terms
DNA, Neoplasm / analysis
Diagnosis, Differential
Gene Rearrangement, T-Lymphocyte / genetics
Middle Aged
Mycosis Fungoides / genetics,  metabolism,  pathology*
Polymerase Chain Reaction
Receptors, Antigen, T-Cell / genetics
Skin Neoplasms / genetics,  metabolism,  pathology*
Reg. No./Substance:
0/DNA, Neoplasm; 0/Receptors, Antigen, T-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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