Document Detail

Hypophosphatemia and calcium nephrolithiasis.
MedLine Citation:
PMID:  15499207     Owner:  NLM     Status:  MEDLINE    
Our knowledge of phosphate balance under physiological and pathological situations has increased substantially during the last decade thanks to the molecular identification of three dissimilar families of sodium-phosphate cotransport systems, two of them almost exclusively expressed in epithelia whereas the third one has a ubiquitous expression. Intracellular proteins such as NHERF1 (sodium-proton exchanger regulatory factor 1) can interact with phosphate transporters through PDZ domains thus regulating the expression of the transporters at the membrane. Moreover, newly acknowledged paracrine/endocrine peptides, such as fibroblast growth factor 23 (FGF23), also affect the activity of phosphate transporters. Renal phosphate leak, related to invalidation (in the mouse) or to mutations (in humans) of the renal phosphate transporter NPT2a, leads to hypophosphatemia on the one hand, and to nephrolithiasis or bone demineralization on the other hand. Similar features are observed during invalidation of NHERF or in case of overproduction of FGF23. These observations highlight the importance of phosphate homeostasis in common diseases such as renal stones or bone loss.
Dominique Prié; Laurent Beck; Caroline Silve; Gérard Friedlander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nephron. Experimental nephrology     Volume:  98     ISSN:  1660-2129     ISO Abbreviation:  Nephron Exp. Nephrol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-22     Completed Date:  2006-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101159770     Medline TA:  Nephron Exp Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  e50-4     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 S. Karger AG, Basel.
Department of Physiology and Inserm U 426, Faculté de Médecine Xavier Bichat, Université Denis Diderot, Paris, France.
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MeSH Terms
Bone Resorption
Fibroblast Growth Factors / physiology
Hypophosphatemia / etiology*,  physiopathology*
Kidney Calculi / genetics*,  physiopathology*
Phosphate Transport Proteins / physiology
Phosphates / metabolism*
Phosphoproteins / genetics,  physiology
Sodium-Hydrogen Antiporter
Reg. No./Substance:
0/Phosphate Transport Proteins; 0/Phosphates; 0/Phosphoproteins; 0/Sodium-Hydrogen Antiporter; 0/fibroblast growth factor 23; 0/sodium-hydrogen exchanger regulatory factor; 62031-54-3/Fibroblast Growth Factors

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