| Hypoperfusion of the motor cortex associated with parkinsonism in dementia with Lewy bodies. | |
| | |
MedLine Citation:
|
PMID: 19854452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This study aimed to investigate the impact of parkinsonism on regional cerebral blood flow (rCBF) in dementia with Lewy bodies (DLB). METHOD: Forty-four probable DLB patients, comprising 13 patients without parkinsonism and 31 patients with parkinsonism, and 16 normal controls were selected for this study. We evaluated the rCBF in each group by means of N-isopropyl-p-[(123)I] iodoamphetamine (IMP) and single photon emission computed tomography (SPECT). The rCBF in the different groups was compared using voxel-by-voxel Statistical Parametrical Mapping (SPM). RESULT: Patients with DLB showed low rCBF in the frontal, temporal, and occipital cortex with relative sparing of the paracentral region. DLB patients with parkinsonism (DLB-P) had lower rCBF in the primary motor cortex (M1) and left supplementary motor area (SMA) than DLB patients without parkinsonism (DLB-nonP). DLB-nonP patients showed decreased rCBF in the left temporo-occipital region. CONCLUSION: This study suggests that two distinct clinical entities are involved in DLB. In addition, CBF changes in the M1 and SMA are seen in the early stages of Parkinson's disease. This result would help in diagnosing DLB in the context of Lewy body (LB) disease. |
| | |
Authors:
|
Ryuichi Takahashi; Kazunari Ishii; Kenichi Shimada; Shingo Ohkawa; Yo Nishimura |
Publication Detail:
|
Type: Journal Article Date: 2009-10-24 |
Journal Detail:
|
Title: Journal of the neurological sciences Volume: 288 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-07 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 88-91 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Nishi-Kobe Medical Center, Kobe, Hyogo, Japan. ryuichi59@yahoo.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Amphetamines / diagnostic use Brain Mapping Cerebrovascular Circulation / physiology Female Hallucinations / physiopathology, radionuclide imaging Humans Lewy Body Disease / complications*, physiopathology*, radionuclide imaging Male Motor Cortex / blood supply*, radionuclide imaging Neuropsychological Tests Parkinson Disease / etiology*, physiopathology*, radionuclide imaging Radiopharmaceuticals / diagnostic use Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
|
0/Amphetamines; 0/Radiopharmaceuticals; 21894-72-4/4-iodoamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevated monocytes in patients with critical limb ischemia diminish after bypass surgery.
Next Document: Long-term divergent tidal flat benthic community recovery following hypoxia-induced mortality.