Document Detail

Hypoperfusion of the motor cortex associated with parkinsonism in dementia with Lewy bodies.
MedLine Citation:
PMID:  19854452     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study aimed to investigate the impact of parkinsonism on regional cerebral blood flow (rCBF) in dementia with Lewy bodies (DLB). METHOD: Forty-four probable DLB patients, comprising 13 patients without parkinsonism and 31 patients with parkinsonism, and 16 normal controls were selected for this study. We evaluated the rCBF in each group by means of N-isopropyl-p-[(123)I] iodoamphetamine (IMP) and single photon emission computed tomography (SPECT). The rCBF in the different groups was compared using voxel-by-voxel Statistical Parametrical Mapping (SPM). RESULT: Patients with DLB showed low rCBF in the frontal, temporal, and occipital cortex with relative sparing of the paracentral region. DLB patients with parkinsonism (DLB-P) had lower rCBF in the primary motor cortex (M1) and left supplementary motor area (SMA) than DLB patients without parkinsonism (DLB-nonP). DLB-nonP patients showed decreased rCBF in the left temporo-occipital region. CONCLUSION: This study suggests that two distinct clinical entities are involved in DLB. In addition, CBF changes in the M1 and SMA are seen in the early stages of Parkinson's disease. This result would help in diagnosing DLB in the context of Lewy body (LB) disease.
Ryuichi Takahashi; Kazunari Ishii; Kenichi Shimada; Shingo Ohkawa; Yo Nishimura
Publication Detail:
Type:  Journal Article     Date:  2009-10-24
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  288     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
Department of Neurology, Nishi-Kobe Medical Center, Kobe, Hyogo, Japan.
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MeSH Terms
Aged, 80 and over
Amphetamines / diagnostic use
Brain Mapping
Cerebrovascular Circulation / physiology
Hallucinations / physiopathology,  radionuclide imaging
Lewy Body Disease / complications*,  physiopathology*,  radionuclide imaging
Motor Cortex / blood supply*,  radionuclide imaging
Neuropsychological Tests
Parkinson Disease / etiology*,  physiopathology*,  radionuclide imaging
Radiopharmaceuticals / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Amphetamines; 0/Radiopharmaceuticals; 21894-72-4/4-iodoamphetamine

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