Document Detail


Hyponatremic seizure in a child using desmopressin for nocturnal enuresis.
MedLine Citation:
PMID:  9529469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intranasal desmopressin has been used extensively to treat primary nocturnal enuresis. While it has proven to be a safe, effective agent for many who are affected by this condition, the potential for complications exists. OBJECTIVES: To report a case of severe hyponatremia associated with a generalized tonic-clonic seizure in a 10-year-old boy who had been receiving intranasal desmopressin nightly for nocturnal enuresis and to briefly review therapeutic options for nocturnal enuresis; and to present the role of desmopressin. SETTING: Georgetown University Medical Center, Washington, DC. INTERVENTION: Fluid restriction and intravenous isotonic saline solution with 5% dextrose was administered to raise the serum sodium level. OUTCOME: Prevention of further seizures with normalization of serum sodium levels without any obvious neurological sequelae. CONCLUSIONS: This case illustrates the importance of weighing the benefits and risks of intranasal desmopressin therapy.
Authors:
M B Donoghue; M E Latimer; H L Pillsbury; J H Hertzog
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  152     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-16     Completed Date:  1998-04-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
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MeSH Terms
Descriptor/Qualifier:
Child
Deamino Arginine Vasopressin / adverse effects*,  therapeutic use
Enuresis / drug therapy*
Epilepsy, Tonic-Clonic / etiology*
Humans
Hyponatremia / chemically induced*,  complications
Male
Renal Agents / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Renal Agents; 16679-58-6/Deamino Arginine Vasopressin
Comments/Corrections
Comment In:
Arch Pediatr Adolesc Med. 1998 Oct;152(10):1037-8   [PMID:  9790620 ]
Arch Pediatr Adolesc Med. 1998 Sep;152(9):930-1   [PMID:  9743047 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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