Document Detail

Hyponatremia in neurological patients: cerebral salt wasting versus inappropriate antidiuretic hormone secretion.
MedLine Citation:
PMID:  17952405     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or with the cerebral salt-wasting syndrome (CSWS). DESIGN: Clinical, controlled, prospective study. SETTING: Department of intensive care of a tertiary care academic hospital. PATIENTS: Forty acute neurological patients with hyponatremia suggesting SIADH or CSWS (20) or with normonatremia (20). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Measurement of clinical and biological variables. Measurement of blood, plasma, and red blood cell volumes to discriminate SIADH and CSWS. Renal, adrenal and thyroid functions were normal in all patients. Average blood, plasma, and red blood cell volumes were 54, 37 and 17ml/kg in control patients and 54, 37 and 18ml/kg in hyponatremic patients, respectively. CONCLUSIONS: The adequate blood volumes in hyponatremic patients confirm the diagnosis of SIADH and do not support the concept of CSWS.
Serge Brimioulle; Carlos Orellana-Jimenez; Adel Aminian; Jean-Louis Vincent
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Publication Detail:
Type:  Journal Article     Date:  2007-10-19
Journal Detail:
Title:  Intensive care medicine     Volume:  34     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Lennik Road 808, 1070 Brussels, Belgium.
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MeSH Terms
Brain Chemistry
Brain Diseases, Metabolic / metabolism*
Brain Injuries / metabolism
Clinical Trials as Topic
Early Diagnosis
Hyponatremia / diagnosis,  physiopathology*
Inappropriate ADH Syndrome / diagnosis*,  physiopathology
Middle Aged
Prospective Studies
Sodium / metabolism*
Water-Electrolyte Imbalance / metabolism*
Reg. No./Substance:

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