| Hyponatremia in heart failure. | |
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MedLine Citation:
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PMID: 19850560 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Hyponatremia is one of the newer and emerging risk factors for an adverse prognosis in chronic heart failure. Why decreased serum sodium is associated with worse prognosis remains unclear. It may reflect worsening heart failure and the deleterious effects of activation of neurohormones. The mechanism of hyponatremia in heart failure also remains unclear. A relatively greater degree of free-water retention compared to sodium retention is probably the major mechanism. The treatment of significant hyponatremia in heart failure is difficult. The conventional treatments such as fluid restriction, infusion of hypertonic saline, and aggressive diuretic therapies are not usually effective. Vasopressin receptor antagonists have been shown to enhance aquaresis and correct hyponatremia. However, long-term beneficial effects of such treatments in chronic heart failure have not been documented. |
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Authors:
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Kanu Chatterjee |
Publication Detail:
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Type: Journal Article Date: 2009-10-21 |
Journal Detail:
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Title: Journal of intensive care medicine Volume: 24 ISSN: 1525-1489 ISO Abbreviation: J Intensive Care Med Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610344 Medline TA: J Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 347-51 Citation Subset: IM |
Affiliation:
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University of California, San Francisco, California, USA. chatterj@medicine.ucsf.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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