Document Detail

Hyponatremia and brain injury: absence of alterations of serum brain natriuretic peptide and vasopressin.
MedLine Citation:
PMID:  20069215     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study any possible relation between hyponatremia following brain injury and the presence of cerebral salt-wasting syndrome (CSWS) or the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), and if vasopressin, brain natriuretic peptide (BNP) and aldosterone have a role in its mechanism. METHOD: Patients with brain injury admitted to the intensive care unit were included and had their BNP, aldosterone and vasopressin levels dosed on day 7. RESULTS: Twenty six adult patients were included in the study. Nine (34.6%) had hyponatremia and presented with a negative water balance and higher values of urinary sodium, serum potassium and diuresis than patients with normonatremia. The serum levels of BNP, aldosterone, and vasopressin were normal and no relation was observed between plasma sodium and BNP, aldosterone or vasopressin. CONCLUSION: The most likely cause of hyponatremia was CSWS and there was no correlation between BNP, aldosterone and vasopressin with serum sodium level.
Karina Nascimento Costa; Helen Mayumi Nakamura; Leonardo Rodrigues da Cruz; Lucas Sampaio Valente Fernandes de Miranda; Rubens Carneiro dos Santos-Neto; Susyanne de Lavor Cosme; Luiz Augusto Casulari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  67     ISSN:  1678-4227     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1037-44     Citation Subset:  IM    
Intensive Care Unit, Hospital de Base do Distrito Federal, Brasília, DF, Brazil.
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MeSH Terms
Aldosterone / blood*
Brain Diseases, Metabolic / blood,  complications,  diagnosis
Brain Injuries / blood*,  complications
Hyponatremia / blood*,  diagnosis,  etiology
Inappropriate ADH Syndrome / blood,  complications,  diagnosis
Middle Aged
Natriuretic Peptide, Brain / blood*
Vasopressins / blood*
Young Adult
Reg. No./Substance:
11000-17-2/Vasopressins; 114471-18-0/Natriuretic Peptide, Brain; 52-39-1/Aldosterone

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