Document Detail

Hyponatremia associated with Ipilimumab-induced hypophysitis.
MedLine Citation:
PMID:  21264545     Owner:  NLM     Status:  Publisher    
A 75-year-old woman with a history of stage IV metastatic melanoma underwent treatment with the CTLA-4 blocking agent Ipilimumab. She presented 2 months after initiating treatment with a severe headache. Laboratories were consistent with severe hyponatremia. MRI of the brain revealed enlargement of the pituitary gland, enhancement of the infundibulum, and an enhancing, centrally necrotic foci in the anterior pituitary. Based on the clinical and radiographic findings, she was diagnosed with treatment-related syndrome of inappropriate antidiuretic hormone secretion (SIADH). Effective treatment consisted of fluid restriction, hyperosmolar therapy, and steroids.
Zachary R Barnard; Brian P Walcott; Kristopher T Kahle; Brian V Nahed; Jean Valery Coumans
Related Documents :
52635 - Suitability of the azocoupling reaction with 1-naphthyl-beta-d-glucoside for the histoc...
5673215 - Lethal complications of the ehlers-danlos syndrome.
14666965 - Coronary arteriomegaly in a patient with ehlers-danlos syndrome and multiple aneurysms-...
21418035 - The pluripotential effects of hypolipidemic treatment for polycystic ovary syndrome (pc...
9227955 - Paraneoplastic neuromuscular syndromes.
22678935 - Sweet's syndrome associated with hashimoto's thyroiditis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-25
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  -     ISSN:  1559-131X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, 02114, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  RRP22: a novel neural tumor suppressor for astrocytoma.
Next Document:  Safety and efficacy of gemcitabine plus cisplatin combination in pretreated metastatic breast cancer...