Document Detail

Hyponatremia associated coma due to pituitary apoplexy in early pregnancy: a case report.
MedLine Citation:
PMID:  19916872     Owner:  NLM     Status:  MEDLINE    
Pituitary apoplexy in pregnancy is rare. Its clinical features may range from unspecific complaints to panhypopituitarism resulting even in coma and death. Therefore, alertness to signs and symptoms of acute loss of pituitary function in pregnancy is mandatory. We report a woman in her 7th week of her first gestation presenting with sudden coma due to severe hyponatremia. Secondary adrenal insufficiency could be identified as the underlying cause. Panhypopituitarism including central diabetes insipidus and spontaneous abortion developed during the follow-up. Magnetic resonance imaging showed pituitary apoplexy without a pre-existing pituitary mass. The clinical course was notable for severe complications, including neurological deficits through cerebral ischemia, but eventual recovery could be achieved. We discuss the diagnostic difficulties in the evaluation of pituitary disease in pregnancy.
Ina Krull; Emanuel Christ; Christian Philipp Kamm; Christoph Ganter; Rahel Sahli
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-12     Completed Date:  2010-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern, Bern, Switzerland.
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MeSH Terms
Coma / blood*
Hyponatremia / blood*,  diagnosis,  therapy
Magnetic Resonance Imaging
Pituitary Apoplexy / blood*,  diagnosis,  therapy
Pregnancy Complications / blood*,  diagnosis,  therapy

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