| Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis. | |
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MedLine Citation:
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PMID: 23146154 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE). METHODS: This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted. RESULTS: A total of 92 patients were included, with a mean age of 36±9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the treatment of choice in 81% of the cases. Death occurred in 13 cases (14.1%). Low serum sodium level correlated directly with AKI and mortality. Male gender (OR 7.89, 95% CI 1.22-50.90, p = 0.03) and hyponatremia at admission (OR 4.73, 95% CI 1.22-18.30, p = 0.02) were predictors for AKI. Independent risk factors for death were AKI (OR 8.3, 95% CI 1.4-48.2, p < 0.0001) and hyponatremia (OR 9.9, 95% CI 1.2-96.3, p < 0.0001). CONCLUSION: AKI and hyponatremia are frequent in TE. Hyponatremia on admission is highly associated with AKI and mortality. |
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Authors:
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Alexandre B Libório; Geraldo B Silva Jr; Carolina G C H Silva; Francisco J C Lima Filho; Adalberto Studart Neto; Willy Okoba; Veralice M S de Bruin; Sônia M H A Araújo; Elizabeth F Daher |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
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Title: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases Volume: - ISSN: 1678-4391 ISO Abbreviation: Braz J Infect Dis Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812937 Medline TA: Braz J Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Editora Ltda. All rights reserved. |
Affiliation:
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School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza, CE, Brazil. |
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