Document Detail

Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis.
MedLine Citation:
PMID:  23146154     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE).
METHODS: This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted.
RESULTS: A total of 92 patients were included, with a mean age of 36±9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the treatment of choice in 81% of the cases. Death occurred in 13 cases (14.1%). Low serum sodium level correlated directly with AKI and mortality. Male gender (OR 7.89, 95% CI 1.22-50.90, p = 0.03) and hyponatremia at admission (OR 4.73, 95% CI 1.22-18.30, p = 0.02) were predictors for AKI. Independent risk factors for death were AKI (OR 8.3, 95% CI 1.4-48.2, p < 0.0001) and hyponatremia (OR 9.9, 95% CI 1.2-96.3, p < 0.0001).
CONCLUSION: AKI and hyponatremia are frequent in TE. Hyponatremia on admission is highly associated with AKI and mortality.
Alexandre B Libório; Geraldo B Silva; Carolina G C H Silva; Francisco J C Lima Filho; Adalberto Studart Neto; Willy Okoba; Veralice M S de Bruin; Sônia M H A Araújo; Elizabeth F Daher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-10
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  16     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-06-19     Revised Date:  2013-08-05    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  558-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Editora Ltda. All rights reserved.
School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza, CE, Brazil.
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MeSH Terms
AIDS-Related Opportunistic Infections / complications*,  mortality
Acute Kidney Injury / etiology*,  mortality
Cohort Studies
Hospital Mortality
Hyponatremia / etiology*,  mortality
Retrospective Studies
Toxoplasmosis, Cerebral / complications*,  mortality

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