Document Detail

Hyponatremia and hypokalemia in patients on peritoneal dialysis.
MedLine Citation:
PMID:  21121953     Owner:  NLM     Status:  MEDLINE    
Hypokalemia occurs in up to 60% of patients on peritoneal dialysis (PD) for end-stage renal disease. It can be associated with poor clinical outcomes, including malnutrition and death. New evidence points to a link between hypokalemia and the risk of peritonitis. The serum Na(+) concentration is determined by the ratio of exchangeable Na(+) and K(+) to total body water. Hyponatremia may be caused by excessive thirst, a particular problem in patients on PD. Consistent with the relationship among the serum sodium concentration, total body cation content, and total body water, hyponatremia may also be caused by total body potassium depletion. Ultra-low sodium dialysis fluid may prove to have an important role in management of fluid overload and hypertension in patients on PD. Surprisingly, it is not associated with significant hyponatremia, for reasons that remain to be elucidated.
Ron Zanger
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-12-02
Journal Detail:
Title:  Seminars in dialysis     Volume:  23     ISSN:  1525-139X     ISO Abbreviation:  Semin Dial     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-12-23     Completed Date:  2011-05-17     Revised Date:  2011-06-13    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-80     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Division of Nephrology, UMDNJ-Robert Wood Johnson Medical School, Cooper University Hospital, Camden, New Jersey 08103, USA.
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MeSH Terms
Dialysis Solutions / adverse effects*
Hypokalemia* / blood,  epidemiology,  etiology
Hyponatremia* / blood,  epidemiology,  etiology
Kidney Failure, Chronic / therapy*
Peritoneal Dialysis / adverse effects*
Risk Factors
World Health
Reg. No./Substance:
0/Dialysis Solutions

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