| Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Myeloid Leukemia. | |
| | |
MedLine Citation:
|
PMID: 21762079 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Epigenetic changes play an important role in cancer pathogenesis. Hypermethylation of DNA generally results in decreased expression of tumor suppressor genes and defective cell cycle control; This is a hallmark of myelodysplastic syndromes (MDS) and acute myeloid leukemia. Fortunately, epigenetic changes are potentially reversible and thus remain an attractive target for anticancer therapy. Inhibitors of DNA methyltransferase cause demethylation of DNA and exert their activity in myelodysplastic syndromes and acute myeloid leukemia with good safety profile. Decitabine and azacytidine are approved for treatment of patients with high-risk MDS. Demethylating agents seem to be the best choice for elderly patients with myelodysplastic syndromes and acute myeloid leukemia, even in case of high risk cytogenetic changes in the karyotype. The mechanisms of action, pharmacokinetics and antileukemic activity of azacytidine and decitabine are the subjects of this review. |
| | |
Authors:
|
Anna Szmigielska-Kapłon; Tadeusz Robak |
Related Documents
:
|
3817399 - Hepatic abscesses as a complication of the sump syndrome: combined surgical and endosco... 1449159 - Common bile duct obstruction due to pancreatic involvement in the von hippel-lindau syn... 64119 - Exocrine pancreatic insufficiency syndrome in cba/j mice. ii. biochemical studies. 4018439 - Plasma apolipoprotein a-iv levels decrease in patients with chronic pancreatitis and ma... 12754389 - In vivo effect of pancreatic phospholipase a2 on the arachidonic acid cascade. 3716149 - Histopathology of the chick pancreas following pancreatic duct ligation. 17013909 - Neurofilament heavy-chain nfh(smi35) in cerebrospinal fluid supports the differential d... 19212549 - One of the rarest syndromes in dentistry: gardner syndrome. 20390289 - Grisel's syndrome--a rare complication following "small" operations and infections in t... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-15 |
Journal Detail:
|
Title: Current cancer drug targets Volume: - ISSN: 1873-5576 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101094211 Medline TA: Curr Cancer Drug Targets Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, 93-510 Lodz, ul. Ciołkowskiego 2, Poland. robaktad@csk.umed.lodz.pl. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeting Epigenetics through Histone Deacetylase Inhibitors in Acute Lymphoblastic Leukemia.
Next Document: Targeting ATP7A to Increase the Sensitivity of Neuroblastoma Cells to Retinoid Therapy.