Document Detail

Hypomagnesemic hypocalcemia in chronic renal failure.
MedLine Citation:
PMID:  8430677     Owner:  NLM     Status:  MEDLINE    
Hypomagnesemic hypocalcemia in chronic renal disease is a rare finding. Controversy remains regarding the role of decreased magnesium in producing impaired parathyroid hormone (PTH) secretion versus target organ unresponsiveness to PTH. We describe six patients with severe chronic renal disease in whom hypocalcemia and hypomagnesemia were detected. Five patients had chronic interstitial nephropathy; all of them showed renal magnesium wasting. One patient had chronic glomerulonephritis and a malabsorption syndrome and showed a low rate of urinary excretion of magnesium. The administration of magnesium increased calcium levels in all patients. We have found elevated PTH levels in absolute terms, which, however, were inappropriate to correct hypocalcemia; the PTH levels increased in three patients and not in the other three after magnesium replacement. We conclude that in patients with tubulointerstitial nephropathies, chronic renal losses of magnesium can produce hypomagnesemic hypocalcemia.
A Torralbo; J Portoles; A J Perez Perez; A Barrientos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  21     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-05     Completed Date:  1993-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Nephrology Service, Hospital Universitario San Carlos, Madrid, Spain.
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MeSH Terms
Hypocalcemia / etiology*
Kidney / physiopathology
Kidney Failure, Chronic / complications*,  physiopathology
Magnesium / blood*
Magnesium Sulfate / therapeutic use
Middle Aged
Parathyroid Hormone / blood
Reg. No./Substance:
0/Parathyroid Hormone; 7439-95-4/Magnesium; 7487-88-9/Magnesium Sulfate

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