Document Detail

Hypomagnesemia resulting from adrenaline infusion in ewes: its relation to lipolysis.
MedLine Citation:
PMID:  892696     Owner:  NLM     Status:  MEDLINE    
Intravenous infusion of adrenaline (40 microgram Kg-1 h-1 for 5 hrs) causes hypomagnesemia in ewes. Hypomagnesemia is increased by phentolamine and inhibited by propranolol. Thyroidectomy, with thyroxine supplementation, does not inhibit the hypomagnesemia caused by adrenaline and phentolamine. Sodium nicotinate (15 mg Kg-1 h-1 for 5 hrs) inhibits the increase in non-esterified fatty acids and hypomagnesemia resulting from infusion of adrenaline and phentolamine. Sodium nicotinate inhibits the increase in non-esterified fatty acids and hypomagnesemia resulting from theophylline infusion (20 mg Kg-1 h-1 for 90 min). It is concluded that an increase in the level of intra-cellular cyclic AMP due to beta adrenergic stimulation by adrenaline or to inhibition of phosphodiesterases by theophylline, results in hypomagnesemia which seems to be correlated with stimulation of lipolysis.
Y Rayssiguier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  9     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
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MeSH Terms
Epinephrine / pharmacology*
Fatty Acids, Nonesterified / blood*
Magnesium / blood*
Nicotinic Acids / pharmacology
Phentolamine / pharmacology
Propranolol / pharmacology
Theophylline / pharmacology
Thyroxine / metabolism
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Nicotinic Acids; 50-60-2/Phentolamine; 51-43-4/Epinephrine; 525-66-6/Propranolol; 58-55-9/Theophylline; 7439-95-4/Magnesium; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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