| Hypomagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation. | |
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MedLine Citation:
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PMID: 10672134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the role of electrolyte imbalance in cardiac arrhythmias associated with congestive heart failure. DESIGN: Serum magnesium and potassium levels, urine magnesium excretion and the incidence of ventricular arrhythmias were assessed throughout the study. The patients who displayed complex arrhythmias after the first week of hospital medication were randomized 2:1 to double-blind magnesium supplementation or placebo. SETTING: The study was carried out in one municipal hospital, providing primary care. SUBJECTS: A total of 588 consecutive patients were screened for eligibility (clinical heart failure >/=6 months; NYHA class II-IV; left ventricular ejection fraction </=40%; sinus rhythm; serum creatinine </=2 mg dL-1). A total of 78 patients entered and 68 patients completed the study. INTERVENTIONS: Intravenous administration of magnesium (magnesium sulphate 8 g in 250 mL of 5% glucose) or placebo (250 mL of 5% glucose) over 12 h. MAIN OUTCOME MEASURES: (i) Incidence of ventricular arrhythmias in patients with hypomagnesemia; (ii) effects of magnesium supplementation on ventricular arrhythmias. RESULTS: On admission, hypomagnesemia was found in 38% and excessive magnesium loss in 72% of patients. Serum magnesium levels were lower and urine magnesium excretion was greater in patients with complex ventricular arrhythmias, both on admission and after treatment for heart failure. Intravenous administration of magnesium caused a significant decrease in the number of ventricular ectopic beats (P < 0.0001), couplets (P < 0.003) and episodes of nonsustained ventricular tachycardia (P < 0.01). CONCLUSIONS: Hypomagnesemia, probably related to increased urine magnesium excretion, is an essential feature of heart failure associated with complex ventricular arrhythmias. These arrhythmias can be alleviated/abolished by magnesium supplementation. |
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Authors:
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L Ceremuzyński; J Gebalska; R Wolk; E Makowska |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 247 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-01 Completed Date: 2000-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 78-86 Citation Subset: IM |
Affiliation:
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Klinika Kardiologii CMKP, Szpital Grochowski, Warszawa, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arrhythmias, Cardiac / blood*, complications*, physiopathology Confounding Factors (Epidemiology) Double-Blind Method Female Heart Failure / blood*, complications*, physiopathology Heart Rate Humans Magnesium / blood*, therapeutic use* Male Middle Aged Stroke Volume Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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