| Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic rats. | |
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MedLine Citation:
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PMID: 18938206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Flax and pumpkin seeds are a rich source of unsaturated fatty acids, antioxidants and fibers, known to have anti-atherogenic and hepatoprotective activities. These effects were evaluated in Wistar rats fed with 1% cholesterol diet. The study was performed on 30 male rats divided into three groups: a control group (CD), CD-chol group fed diet with 1% cholesterol and MS-chol group fed diet enriched with flax and pumpkin seed mixture. In CD-chol group, total cholesterol TC, triacylglycerol TG in plasma and liver, plasma LDL-C, atherogenic index AI and LDL/HDL ratio significantly increased. In MS-chol group lipid parameters decreased significantly, plasma and liver fatty acid composition showed an increase of PUFAs (ALA and LA), and MUFAs (oleic and eicosaenoic acid) and a decrease of SFA (palmitic and stearic acid). In plasma and liver of MS-chol group, malondialdehyde levels decreased and the efficiency of antioxidant defense system was improved compared to CD-chol group. Liver histological sections showed lipid storage in hepatocytes of CD-chol group and an improvement was noted in MS-chol group. Our results suggested that flax and pumpkin seed mixture had anti-atherogenic and hepatoprotective effects which were probably mediated by unsaturated fatty acids present in seed mixture. |
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Authors:
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M Makni; H Fetoui; N K Gargouri; El M Garoui; H Jaber; J Makni; T Boudawara; N Zeghal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-01 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 46 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-01-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 3714-20 Citation Subset: IM |
Affiliation:
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Animal Physiology Laboratory, Sciences Faculty, UR 08-73, BP 1171, Tunisia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology* Antioxidants / metabolism Body Weight / drug effects Cucurbita / chemistry* Diet Drug-Induced Liver Injury / prevention & control* Fatty Acids / blood, metabolism Fatty Acids, Omega-3 / analysis, pharmacology* Fatty Acids, Omega-6 / analysis, pharmacology* Flax / chemistry* Hypercholesterolemia / blood, drug therapy* Lipid Peroxidation / drug effects Lipids / analysis, blood Liver / drug effects, metabolism Male Protective Agents / pharmacology* Proteins / metabolism Rats Rats, Wistar Seeds / chemistry Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Antioxidants; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Lipids; 0/Protective Agents; 0/Proteins; 0/Thiobarbituric Acid Reactive Substances |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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