| Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. | |
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MedLine Citation:
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PMID: 19960459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proanthocyanidins are the most abundant polyphenols in human diets. Epidemiological studies strongly suggest that proanthocyanidins protect against cardiovascular diseases. Despite the antioxidant and anti-inflammatory properties of these flavonoids, one of the mechanisms by which proanthocyanidins exert their cardiovascular protection is improving lipid homeostasis. Animal studies demonstrate that proanthocyanidins reduce the plasma levels of atherogenic apolipoprotein B-triglyceride-rich lipoproteins and LDL-cholesterol but increase antiatherogenic HDL-cholesterol. The results in humans, however, are less clear. This review summarizes the results that have been published on plasma triglyceride, apolipoprotein B, HDL-cholesterol and LDL-cholesterol levels in humans and animal models in response to proanthocyanidin extracts and proanthocyanidin-rich foods. The physiological processes and biochemical pathways that are related to lipid homeostasis and affected by proanthocyanidin consumption are also discussed. Intestinal lipid absorption, chylomicron secretion by the intestine and VLDL secretion by the liver are the processes that are most repressed by proanthocyanidins, which, therefore, induce hypolipidemic effects. |
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Authors:
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Cinta Blad?; Lluis Arola; Maria-Josepa Salvad? |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 54 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-13 Completed Date: 2010-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 37-59 Citation Subset: IM |
Affiliation:
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Nutrigenomics Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain. mariacinta.blade@urv.cat |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology* Apolipoproteins B / blood, metabolism Cholesterol, HDL / blood, metabolism Cholesterol, LDL / blood, metabolism Diet Humans Lipid Metabolism / drug effects* Phytotherapy Proanthocyanidins / pharmacology* Triglycerides / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Proanthocyanidins; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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