| Hypolipidemic effect of the polysaccharide from Pholiota nameko. | |
| | |
MedLine Citation:
|
PMID: 19815391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This study was conducted to investigate the hypolipidemic effect of the polysaccharide isolated from Pholiota nameko (PNPS-1). METHODS: Hyperlipidemic Wistar rats were treated with PNPS-1 (20, 40, and 60 mg/kg orally). RESULTS: Treatment of hyperlipidemic Wistar rats with PNPS-1 led not only to significant decreases in very low-density lipoprotein/low-density lipoprotein cholesterol (-48.98% and -21.54%, 40 and 60 mg/kg), triacylglycerol (-19.70%, -17.17%, -32.32%), phospholipids (-9.90%, -19.80%, -27.08%), and consequently the atherogenic index (23.61%, 70.42%, 82.85%) and a increase in high-density lipoprotein cholesterol (69.01% and 73.35%, 40 and 60 mg/kg) in serum, but also to significant decreases in total lipids (-10.24% and -33.16%, 40 and 60 mg/kg), total cholesterol (-24.22%, -34.26%, -55.02%), triacylglycerol (-22.53% and -38.50%, 40 and 60 mg/kg), and phospholipids (-27.41%, 60 mg/kg) in the liver. Further, PNPS-1 significantly suppressed lipid peroxidation by decreasing malondialdehyde and increasing antioxidant enzymes in serum (malondialdehyde, 9.94%, -22.22%, -32.75%; superoxide dismutase, 37.26%, 101%, 114%; catalase, 32.2%, 30.02%, 36.74%; glutathione peroxidase, 31.30%, 35.56%, 52.34%) of the 20-, 40-, and 60-mg/kg PNPS-1 groups and in the liver (malondialdehyde, -32.26%, -47.85%; catalase, 97%, 117%; glutathione peroxidase, 70.70%, 78.03%) in the 40- and 60-mg/kg PNPS-1 groups (superoxide dismutase, 24.35%, 67.49%, 234%). PNPS-1 was also effective in lowering body weight and some visceral weights (liver, heart, and kidney) in treated rats, except for the lung. PNPS-1 also ameliorated the pathologic changes in coronary arteries of hyperlipidemic rats. CONCLUSION: These results suggested that PNPS-1 significantly suppresses the development of hyperlipidemia and might be used as a potential therapeutic agent for hyperlipidemia. |
| | |
Authors:
|
Haiping Li; Mingming Zhang; Guiji Ma |
Publication Detail:
|
Type: Journal Article Date: 2009-10-07 |
Journal Detail:
|
Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 26 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-12 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
|
Languages: eng Pagination: 556-62 Citation Subset: IM |
Copyright Information:
|
Crown Copyright 2010. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, Peoples Republic of China. hhppli@163.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antilipemic Agents / administration & dosage* Catalase / analysis, blood Cholesterol, HDL / blood Cholesterol, LDL / blood Glutathione Peroxidase / analysis, blood Hyperlipidemias / blood, drug therapy* Lipids / blood Liver / chemistry, enzymology Male Malondialdehyde / analysis, blood Pholiota / chemistry* Phospholipids / blood Polysaccharides / administration & dosage* Rats Rats, Wistar Superoxide Dismutase / analysis, blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Antilipemic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/PNPS-1 polysaccharide; 0/Phospholipids; 0/Polysaccharides; 0/Triglycerides; 542-78-9/Malondialdehyde; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of phytosterols on copper lipid peroxidation of human low-density lipoproteins.
Next Document: Rifampicin combined regimens for Gram-negative infections: data from the literature.