Document Detail

Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose.
MedLine Citation:
PMID:  11817109     Owner:  NLM     Status:  MEDLINE    
The hypolipidemic effects of pantothenic acid derivatives (phosphopantothenate, panthenol and pantethine) were studied in mice with hypothalamic obesity. Hypothalamic obesity in mice was induced by single injection of aurothioglucose (300 mg/kg body wt, i.p.). All the tested substances were administered during the last 10 days before decapitation (i.m., of dosage equivalent to 150 mg/kg body wt of phosphopantothenate). The studied substances inhibited the weight gain of the animals with hypothalamic obesity over the last 10 days of the experiment. The treatment with aurothioglucose increased food intake and mean body weight, blood glucose level; insulin, serum total cholesterol, triglyceride, the sum of LDL + VLDL and LDL-cholesterol concentration; triglyceride and cholesterol fractions in the liver; triglyceride and FFA content as well as lipoprotein lipase activity in adipose tissue of experimental mice. The administration of the assay compounds lowered food intake and mean body weight, insulin and glucose levels and decreased the content of triglycerides, total cholesterol and cholesterol esters in serum and adipose tissue as well as raised the activity of lipoprotein lipase in adipose tissue and serum lipolytic activity in obese mice. Among the compounds studied the reverse effect of panthenol was especially pronounced. The mechanism of hypolipidemic effects of pantothenic acid derivatives can be related to the reduced resistance to insulin and activation of lipolysis in serum and adipose tissue.
E Naruta; V Buko
Related Documents :
20065959 - Chronic suppression of μ-opioid receptor signaling in the nucleus accumbens attenuates ...
17122359 - Understanding and addressing the epidemic of obesity: an energy balance perspective.
10721889 - Dietary fat intake and regulation of energy balance: implications for obesity.
5011099 - Lipogenesis in human adipose tissue: some effects of nibbling and gorging.
24766669 - Physical activity and sedentary behaviour in relation to cardiometabolic risk in childr...
21470559 - Synthesis of the enantiomer of the oxysterol-antagonist ly295427.
1914359 - Effects of protein and carbohydrate content of diet on drug conjugation.
25036629 - Gut microbial metabolism drives transformation of msh2-deficient colon epithelial cells.
16441919 - Effect of dha supplementation on digestible starch utilization by rainbow trout.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  53     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-12-05     Completed Date:  2002-03-28     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  393-8     Citation Subset:  IM    
Department of Experimental Hepathology, Institute of Biochemistry, National Academy of Sciences, Grodno, Belarus.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / enzymology
Antilipemic Agents / therapeutic use*
Aurothioglucose / toxicity
Hypothalamus / drug effects*
Lipids / blood
Lipoprotein Lipase / blood
Liver / metabolism
Mice, Inbred Strains
Obesity / chemically induced,  drug therapy*,  metabolism
Pantothenic Acid / analogs & derivatives*,  therapeutic use*
Reg. No./Substance:
0/Antilipemic Agents; 0/Lipids; 12192-57-3/Aurothioglucose; 79-83-4/Pantothenic Acid; EC Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of cytochrome P450 (CYP) isozymes in rat placenta through pregnancy.
Next Document:  Frequency and time trends of spontaneous tumors found in B6C3F1 mice oncogenicity studies over 10 ye...