Document Detail


Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats.
MedLine Citation:
PMID:  20645721     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we investigated the effect of fucoidan polysaccharide sulfuric acid ester (FPS) from Laminaria japonica Aresch (Laminariaceae) on hyperlipidemic rats. FPS notably reduced the concentration of serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) of hyperlipidemic rats and increased the concentration of high-density lipoprotein cholesterol (HDL-C) and the activities of lipoprotein lipase (LPL), hepatic lipoprotein (HL), and lecithin cholesterol acyltransferase (LCAT).
Authors:
Ling Huang; Kewei Wen; Xuan Gao; Yonghong Liu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical biology     Volume:  48     ISSN:  1744-5116     ISO Abbreviation:  Pharm Biol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812552     Medline TA:  Pharm Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
Affiliation:
Department of Oncology, Guangdong Provincial People's Hospital, Guangzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Fats / administration & dosage
Disease Models, Animal
Dose-Response Relationship, Drug
Hyperlipidemias / blood,  drug therapy*
Hypolipidemic Agents / isolation & purification,  therapeutic use*
Laminaria / chemistry*
Lipids / blood
Male
Polysaccharides / isolation & purification,  therapeutic use*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Hypolipidemic Agents; 0/Lipids; 0/Polysaccharides; 9072-19-9/fucoidan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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