Document Detail


Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina.
MedLine Citation:
PMID:  20633020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spirulina is free-floating filamentous microalgae growing in alkaline water bodies. With its high nutritional value, Spirulina has been consumed as food for centuries in Central Africa. It is now widely used as nutraceutical food supplement worldwide. Recently, great attention and extensive studies have been devoted to evaluate its therapeutic benefits on an array of diseased conditions including hypercholesterolemia, hyperglycerolemia, cardiovascular diseases, inflammatory diseases, cancer, and viral infections. The cardiovascular benefits of Spirulina are primarily resulted from its hypolipidemic, antioxidant, and antiinflammatory activities. Data from preclinical studies with various animal models consistently demonstrate the hypolipidemic activity of Spirulina. Although differences in study design, sample size, and patient conditions resulting in minor inconsistency in response to Spirulina supplementation, the findings from human clinical trials are largely consistent with the hypolipidemic effects of Spirulina observed in the preclinical studies. However, most of the human clinical trials are suffered with limited sample size and some with poor experimental design. The antioxidant and/or antiinflammatory activities of Spirulina were demonstrated in a large number of preclinical studies. However, a limited number of clinical trials have been carried out so far to confirm such activities in human. Currently, our understanding on the underlying mechanisms for Spirulina's activities, especially the hypolipidemic effect, is limited. Spirulina is generally considered safe for human consumption supported by its long history of use as food source and its favorable safety profile in animal studies. However, rare cases of side-effects in human have been reported. Quality control in the growth and process of Spirulina to avoid contamination is mandatory to guarantee the safety of Spirulina products.
Authors:
Ruitang Deng; Te-Jin Chow
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  28     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  e33-45     Citation Subset:  IM    
Affiliation:
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. DengR@mail.uri.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / adverse effects,  therapeutic use*
Antioxidants / adverse effects,  therapeutic use*
Clinical Trials as Topic
Dietary Supplements* / adverse effects
Evidence-Based Medicine
Humans
Hypolipidemic Agents / adverse effects,  therapeutic use*
Spirulina*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
P20 RR016457/RR/NCRR NIH HHS; P20 RR016457-076989/RR/NCRR NIH HHS; P20-RR016457/RR/NCRR NIH HHS; R01 DK087755-01/DK/NIDDK NIH HHS; R01 DK087755-02/DK/NIDDK NIH HHS; R01-DK087755/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Hypolipidemic Agents
Comments/Corrections

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