| Hypolipidemic and antioxidant activity of Anthocephalus indicus (Kadam) root extract. | |
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MedLine Citation:
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PMID: 20521624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was carried out to explore the anti-diabetic, anti-dyslipoproteinemic and anti-oxidant activities of Anthocephalus indicus root extract in alloxan-induced (150 mg/kg body wt.) diabetic rats. A marked increase in plasma levels of glucose and lipid peroxides accompanied with an elevation in the lipids and apoprotein levels of serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL) following decrease in lipid and protein constituents of high density lipoprotein (HDL) were observed. The alterations in lipoprotein pattern was associated with inhibition of lipolytic and antioxidant enzymes. Oral administration of root extract (500 mg/kg body wt.) for 30 days in dyslipidemic animals resulted in significant decrease in plasma glucose, total cholesterol, phospholipids, triglyceride and lipid peroxides. The decrease of lipids and apoprotein levels of VLDL and LDL were followed by stimulation of plasma post-heparin lipolytic activity and lecithin cholesterol acyltransferase as well as hepatic superoxide dismutase and catalase activities. Lipid and apoprotein levels of HDL were also recovered partially on treatment with root extract. |
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Authors:
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Vishnu Kumar; Farzana Mahdi; Ramesh Chander; Ranjana Singh; Abbas Ali Mahdi; Ashok Kumar Khanna; Sanjay Bhatt; Rajeev Singh Kushwaha; Kalbe Jawad; Jitendra Kumar Saxena; Raj Kumar Singh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of biochemistry & biophysics Volume: 47 ISSN: 0301-1208 ISO Abbreviation: Indian J. Biochem. Biophys. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0310774 Medline TA: Indian J Biochem Biophys Country: India |
Other Details:
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Languages: eng Pagination: 104-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow 226001. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology*, therapeutic use Antioxidants / pharmacology*, therapeutic use Bile Acids and Salts / metabolism Diabetes Mellitus, Experimental / blood, drug therapy, metabolism Fatty Acids / blood, metabolism Feces Lipid Metabolism / drug effects Lipid Peroxides / blood Liver / drug effects, enzymology, metabolism Male Plant Extracts / pharmacology* Plant Roots / chemistry* Rats Trees / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Antioxidants; 0/Bile Acids and Salts; 0/Fatty Acids; 0/Lipid Peroxides; 0/Plant Extracts |
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