| Hypolipidemic and anti-atherogenic activity of aqueous extract of Gleditsia sinensis Lam. in rabbits fed a high-lipids diet. | |
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MedLine Citation:
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PMID: 21718773 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The efficacy of hypolipidemic and anti-atherogenic in Gleditsia sinensis Lam. fruit aqueous extract (GAE) was investigated in Japanese white rabbits fed on high-lipids diet. Rabbits were divided into four groups: the first two groups of rabbits received normal and high-lipids diet, respectively, and the remaining two groups received high-lipids diet supplemented with GAE (12 and 6mg/kg B.W.). The groups with high-lipids diet were administered i.v. with bovine serum albumin (BSA) in the 4th week for atherosclerosis modeling. The concentrations of triglycerides (TGs), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were determined in rabbits at the start of the experiment, in 4th, 8th weeks and at the end of the study (14th week). And the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK) were determined simultaneously. The rabbits were sacrificed and the aorta and liver were removed at the end of the experiment. Atherosclerotic plaques were assessed by oil-red and H&E staining, while the lipids level (TG, TC, LDL-C) in tissue was determined in aorta and liver homogenate. Results showed that GAE could significantly decrease TC and LDL-C levels and retard aortic atherosclerosis. Hence GAE can effectively prevent the progress of atherosclerosis. This is likely due to hypolipidemic effect of GAE. |
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Authors:
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Peng Lai; Jun-Rong Du; Meng-Xue Zhang; Xi Kuang; Yong-Jie Li; Ya-Shu Chen; Yao He |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-21 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: - ISSN: 1872-7573 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Pharmacology & Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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