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Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents.
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MedLine Citation:
PMID:  18472769     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The amine-borane adducts of cyclohexylamine and toluidine were observed to be potent hypolipidemic agents in mice, I.P. and rats orally at 8 mg/kg/day lowering both serum cholesterol and triglyceride levels after 14-16 days. These compounds were able to lower tissue lipids including the cholesterol content of the aorta wall. The agents successfully lower VLDL- and LDL-cholesterol content while elevating HDL-cholesterol content significantly. The agents also modulate lipid regulatory enzyme activities in a manner to reduce liver lipid levels. These studies demonstrate that the nitrogen atom does not have to be apart of the aromatic ring as in heterocyclic-amine borane to afford good hypolipidemic activity in rodents.
Authors:
B S Burnham; S Y Chen; A Sood; B F Spielvogel; I H Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metal-based drugs     Volume:  2     ISSN:  0793-0291     ISO Abbreviation:  Met Based Drugs     Publication Date:  1995  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505939     Medline TA:  Met Based Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-32     Citation Subset:  -    
Affiliation:
Division of Medicinal Chemistry and Natural Products School of Pharmacy University of North Carolina Chapel Hill N.C. 27599-7360 USA.
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Journal Information
Journal ID (nlm-ta): Met Based Drugs
ISSN: 0793-0291
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1995 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 7 Month: 4 Year: 1995
Accepted Day: 5 Month: 5 Year: 1995
Print publication date: Year: 1995
Volume: 2 Issue: 4
First Page: 221 Last Page: 232
ID: 2364981
PubMed Id: 18472769
Publisher Item Identifier: S0793029195000292
DOI: 10.1155/MBD.1995.221

Hypolipidemic Activity of Amine-Borane Aducts of Cyclohexylamine and Toluidine in Rodents
Bruce S. Burnham1
S. Y. Chen1
A. Sood2
Bernard F. Spielvogel2
Iris H. Hall1
1Division of Medicinal Chemistry and Natural ProductsSchool of PharmacyUniversity of North CarolinaChapel HillN.C.27599-7360USA
2Boron Biologicals, Inc.620 Hutton Rd.RaleighN.C.27606USA


Article Categories:
  • Research Article


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