| Hypolipidemic activity of Hibiscus rosa sinensis root in rats. | |
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MedLine Citation:
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PMID: 20361715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis. |
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Authors:
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Vishnu Kumar; Pradyumn Singh; Ramesh Chander; Farzana Mahdi; Sushma Singh; Ranjana Singh; Ashok Kumar Khanna; Jitendra Kumar Saxena; Abbas Ali Mahdi; Vinod Kumar Singh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of biochemistry & biophysics Volume: 46 ISSN: 0301-1208 ISO Abbreviation: Indian J. Biochem. Biophys. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0310774 Medline TA: Indian J Biochem Biophys Country: India |
Other Details:
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Languages: eng Pagination: 507-10 Citation Subset: IM |
Affiliation:
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Department of Biochemistry & Pathology, Era's Lucknow Medical College & Hospital, Lucknow, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology* Cholesterol / metabolism Dietary Fats / adverse effects Hibiscus / chemistry* Hyperlipidemias / chemically induced, metabolism, pathology Liver / drug effects, pathology Male Phytotherapy Plant Extracts / pharmacology* Plant Roots / chemistry* Polyethylene Glycols / pharmacology Rats |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Dietary Fats; 0/Plant Extracts; 0/Polyethylene Glycols; 25301-02-4/tyloxapol; 57-88-5/Cholesterol |
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