| Hypolipidemic activity of Anethum graveolens in rats. | |
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MedLine Citation:
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PMID: 18058989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aerial parts of Anethum graveolens (dillweed) are used in Iran as a hypolipidemic agent. The scientific basis for its use has yet to be established. In this study the hypolipidemic activity of dill powder and its essential oil (its most important fraction) were evaluated in male Wistar rats (180 +/- 20 g) fed a high cholesterol diet. Anethum graveolens essential oil (AGEO) was prepared by hydrodistillation and analysed using GC/MS. AGEO had a yield of 2% and GC/MS analysis showed that alpha-phellandrene (32%), limonene (28%) and carvone (28%) were its major components. Daily oral administration of AGEO to rats at doses of 45, 90 and 180 mg/kg for 2 weeks significantly and in a dose-dependent manner reduced total cholesterol, triglyceride and low density lipoprotein cholesterol (LDL-C). AGEO also increased significantly high density lipoprotein cholesterol (HDL-C). Anethum graveolens powder when added to the diet of animals showed similar effects on serum lipids. It is concluded that Anethum graveolens has significant lipid lowering effects and is a promising cardioprotective agent. |
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Authors:
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Valiollah Hajhashemi; Naser Abbasi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 22 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 372-5 Citation Subset: IM |
Affiliation:
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Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I. R. Iran. vhajhashemi@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anethum graveolens
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chemistry* Animals Antilipemic Agents / administration & dosage, pharmacology* Cholesterol / blood Cholesterol, Dietary / administration & dosage, pharmacology Cholesterol, HDL / blood, drug effects Cholesterol, LDL / blood, drug effects Dose-Response Relationship, Drug Male Oils, Volatile / administration & dosage, chemistry, pharmacology* Phytotherapy* Plant Components, Aerial / chemistry Plant Extracts / administration & dosage, pharmacology* Rats Rats, Wistar Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Oils, Volatile; 0/Plant Extracts; 0/Triglycerides; 57-88-5/Cholesterol |
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