| Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice. | |
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MedLine Citation:
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PMID: 20354346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pleurotus eryngii water extract (PEE), which showed the most significant inhibitory activity against pancreatic lipase in vitro among eight edible mushrooms, was investigated to determine the mechanism of its anti-lipase activity in vitro and its hypolipidemic effect in fat-loaded mice. The inhibitory effects of mushroom extracts on pancreatic lipase activity were examined using 4-methylumbelliferyl oleate (4-MUO) or trioleoylglycerol emulsified with lecithin, gum arabic or Triton X-100 as a substrate. For in vivo experiments, blood samples were taken after oral administration of corn oil and [(3)H]trioleoylglycerol with or without PEE to food-deprived mice. PEE inhibited hydrolysis of 4-MUO and trioleoylglycerol emulsified with lecithin or Triton X-100, but not that of trioleoylglycerol emulsified with gum arabic. PEE suppressed the elevations of plasma and chylomicron triacylglycerol levels after oral administration of corn oil, but had no effect on lipoprotein lipase activity. [(3)H]Trioleoylglycerol absorption was also decreased by administration of PEE. The results of in vitro studies suggest that PEE may prevent interactions between lipid emulsions and pancreatic lipase. The hypolipidemic effect of PEE in fat-loaded mice may be due to low absorption of fat caused by the inhibition of pancreatic lipase. |
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Authors:
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Tomohiro Mizutani; Satoshi Inatomi; Akihiro Inazu; Ei Kawahara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 56 ISSN: 1881-7742 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 48-53 Citation Subset: IM |
Affiliation:
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Mushroom Research Laboratory, Hokuto Corporation, Nagano, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology*, therapeutic use Biological Products / pharmacology*, therapeutic use Chylomicrons Corn Oil / administration & dosage Dietary Fats / metabolism* Disease Models, Animal Emulsions Food Deprivation Hydrolysis Hymecromone / analogs & derivatives, metabolism Hyperlipidemias / drug therapy Lipase / antagonists & inhibitors* Lipoprotein Lipase / antagonists & inhibitors* Male Mice Mice, Inbred ICR Obesity / drug therapy* Phytotherapy Plant Extracts / pharmacology*, therapeutic use Pleurotus* Triglycerides / blood Triolein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Biological Products; 0/Chylomicrons; 0/Dietary Fats; 0/Emulsions; 0/Plant Extracts; 0/Triglycerides; 122-32-7/Triolein; 18323-58-5/4-methylumbelliferyl oleate; 8001-30-7/Corn Oil; 90-33-5/Hymecromone; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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