| The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. | |
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MedLine Citation:
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PMID: 20017484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hibiscus sabdariffa extract (HSE) was shown to lower the plasma lipid level and reduce the liver damage. In the present study, we investigated if Hibiscus sabdariffa polyphenols (HPE) exerted a hypolipidemic effect and its putative mechanism on liver. HPE exhibited more potency to decrease plasma cholesterol and LDL cholesterol than the crude extract HSE, and increased HDL cholesterol dose-dependently. It decreased the lipid content of hepatocyte through the activation of AMPK and reduction of SREBP-1, thus inhibiting the expression of fatty acid synthase and HMG-CoA reductase. LDLR and LDL binding of HepG2 cells were enhanced when treated with HPE. In conclusion, HPE is worthy of being further investigated and could be developed as an adjunctive for hepatic lipid control and hypolipidemic therapy. |
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Authors:
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Mon-Yuan Yang; Chiung-Huei Peng; Kuei-Chuan Chan; Yi-Sun Yang; Chien-Ning Huang; Chau-Jong Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 850-9 Citation Subset: IM |
Affiliation:
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Institute of Biochemistry and Biotechnology, Chung-Shan Medical University, Taichung 402, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / administration & dosage* Cricetinae Down-Regulation* Fatty Acid Synthetase Complex / genetics, metabolism Flavonoids / administration & dosage* Gene Expression Regulation, Enzymologic / drug effects Hep G2 Cells Hibiscus / chemistry* Humans Hydroxymethylglutaryl CoA Reductases / genetics, metabolism Lipid Metabolism / drug effects* Lipids / biosynthesis Lipogenesis / drug effects* Liver / drug effects, enzymology, metabolism* Male Mesocricetus Phenols / administration & dosage* Plant Extracts / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Flavonoids; 0/Lipids; 0/Phenols; 0/Plant Extracts; 0/polyphenols; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 6.-/Fatty Acid Synthetase Complex |
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