| Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice. | |
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MedLine Citation:
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PMID: 20642878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oligonol was orally administered at 10 or 20 mg/kg body weight per d for 8 weeks to db/db mice with type 2 diabetes, and its effects were compared with those of the vehicle in db/db and m/m (misty, non-diabetic) mice. Serum and renal biochemical factors, protein expressions related to lipid metabolism and inflammation, and advanced glycation endproducts were measured. There were significant reductions in the serum lipid concentration, reactive oxygen species (ROS) and lipid peroxidation, as well as improvements in renal function parameters. In addition, oligonol treatment significantly decreased ROS levels and lipid peroxidation in the kidney. In particular, the renal lipid contents such as TAG and total cholesterol were significantly reduced in the oligonol-administered groups through the up-regulation of PPARα and down-regulation of sterol regulatory element-binding protein-1 in db/db mice. Moreover, oligonol inhibited non-fluorescent AGE formation and their receptor expression, suggesting that it could effectively inhibit AGE development caused by oxidative stress and/or dyslipidaemia in the kidney of db/db mice. Furthermore, augmented expressions of NF-κBp65, cyclo-oxygenase-2 and inducible NO synthase were down-regulated to the levels of m/m mice in the group given oligonol at 20 mg/kg. This means that oligonol would act as a regulator in the inflammatory response of type 2 diabetes. The present results suggest that oligonol could have renoprotective effects against abnormal lipid metabolism and ROS-related AGE formation in type 2 diabetes. |
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Authors:
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Jeong Sook Noh; Hyun Young Kim; Chan Hum Park; Hajime Fujii; Takako Yokozawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-20 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1120-8 Citation Subset: IM |
Affiliation:
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Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology, therapeutic use* Antioxidants / pharmacology, therapeutic use* Biological Markers Catechin / analogs & derivatives*, chemistry, pharmacology, therapeutic use Diabetes Complications / prevention & control Diabetes Mellitus, Experimental / blood Diabetes Mellitus, Type 2 / blood* Fruit / chemistry Glycosylation End Products, Advanced / metabolism Hyperlipidemias / drug therapy* Kidney / drug effects, pathology Kidney Diseases / etiology, prevention & control Litchi / chemistry* Male Mice Organ Size Oxidative Stress Phenols / chemistry, pharmacology, therapeutic use* Reactive Oxygen Species Thiobarbituric Acid Reactive Substances |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Antioxidants; 0/Biological Markers; 0/Glycosylation End Products, Advanced; 0/Phenols; 0/Reactive Oxygen Species; 0/Thiobarbituric Acid Reactive Substances; 0/oligonol; 154-23-4/Catechin |
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