| Hypolipidaemic and antioxidant activities of Ficus microcarpa (L.) in hypercholesterolemic rats. | |
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MedLine Citation:
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PMID: 21740287 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Saponifiable and unsaponifiable fractions of Ficus microcarpa leaves hexane extract have been phytochemically studied and evaluated for its hypolipidaemic and antioxidant effects in hypercholesterolemic rats. The effect of the extract on the lipid profile was assessed by measuring the levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, phospho and total lipids. Lipid peroxides, glutathione and superoxide dismutase were measured as antioxidants. The work was extended to evaluate liver function indices as well as the histopathological picture of the liver after treatment. Treatment with leaves extract (500?mg?kg(?1) body weight) 5 times/week for 9 weeks at the same time of cholesterol administration (30?mg/0.3?mL 0.7% tween/animal) recorded an improvement of lipid profile, antioxidants, liver function enzymes and the liver histopathological picture. The lipoidal matters of the unsaponifiable fraction of the hexane extract by GC/MS led to the identification of 22 compounds, while saponifiable fraction by (MS/MS) technique led to identification of 13 unsaturated and saturated fatty acid methyl ester derivatives. It can be concluded that the hexane extract of F. microcarpa L has been proved to have hypolipidaemic and antioxidant effects in hypercholesterolemic rats through its role in counteracting LDL oxidation, enhancement of HDL synthesis and inhibition of lipid peroxidation. |
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Authors:
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Nagwa E Awad; Ahmed A Seida; Manal A Hamed; Marwa M Elbatanony |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Natural product research Volume: 25 ISSN: 1478-6427 ISO Abbreviation: Nat. Prod. Res. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 1202-7 Citation Subset: IM |
Affiliation:
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a Pharmacognosy Department , National Research Centre , Cairo , Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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