| Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. | |
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MedLine Citation:
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PMID: 21056640 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders. |
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Authors:
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Vincenzo Mollace; Iolanda Sacco; Elzbieta Janda; Claudio Malara; Domenica Ventrice; Carmen Colica; Valeria Visalli; Saverio Muscoli; Salvatore Ragusa; Carolina Muscoli; Domenicantonio Rotiroti; Franco Romeo |
Publication Detail:
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Type: Journal Article Date: 2010-11-04 |
Journal Detail:
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Title: Fitoterapia Volume: 82 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 309-16 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmacobiological Sciences, University Magna Graecia, Catanzaro, Italy; C.E.T.A (Centro d'Eccellenza in Tossicologia Alimentare), ARPACal, Catanzaro, Italy; Vascular Medicine and Atherosclerosis Unit, Cardiology, Salus Medical Center, Marinella di Bruzzano, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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