| Hypolipaemic activity of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate) and its analogues in normolipaemic rats. | |
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MedLine Citation:
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PMID: 7194054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypolipaemic potential of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, ML 1024, Duolip) was assessed in conjunction with a series of analogous new theophylline derivatives and clofibrate (CPIB) by a short-term screening test in normolipaemic rats. The significant cholesterol and triglyceride-lowering effect of ML 1024 was comparable to that observed for CPIB over the 50-300 mg/kg dose range evaluated and contrasted with the relative inactivity associated with its chemical analogues. |
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Authors:
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A V Ginocchio; G Metz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 30 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1980 |
Date Detail:
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Created Date: 1981-05-13 Completed Date: 1981-05-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 2032-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents* Cholesterol / blood Clofibrate / analogs & derivatives*, pharmacology Dose-Response Relationship, Drug Lipids / blood Male Rats Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Lipids; 0/Triglycerides; 54504-70-0/etofyllinclofibrate; 57-88-5/Cholesterol; 637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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