Document Detail

Hypokinetic stress and neuronal porosome complex in the rat brain: The electron microscopic study.
MedLine Citation:
PMID:  22571877     Owner:  NLM     Status:  Publisher    
Porosomes are the universal secretory machinery in cells, where membrane-bound secretory vesicles transiently dock and fuse to release intravesicular contents to the outside of the cell during cell secretion. Studies using atomic force microscopy, electron microscopy, electron density and 3D contour mapping, provided rich nanoscale information on the structure and assembly of proteins within the neuronal porosome complex in normal brain. However it remains uncertain whether pathological conditions that alter process of neurotransmission, provoke alterations in the porosome structure also. To determine if porosomes are altered in disease states, the current study was undertaken for first time using high resolution electron microscope. One of pathologies that produce subtle alteration at the presynaptic terminals has been demonstrated to be hypokinetic stress. The central nucleus of amygdale is the brain region, where such alterations are mostly expressed. We have examined the width and depth of the neuronal porosome complex and their alterations provoked by chronic hypokinetic stress in above mentioned limbic region. Specifically, we have demonstrated that despite alterations in the presynaptic terminals and synaptic transmission provoked by this pathological condition in this region, the final step/structure in neurosecretion - the porosome - remains unaffected: the morphometric analysis of the depth and diameter of this cup-shaped structure at the presynaptic membrane point out to the heterogeneity of porosome dimensions, but with unchanged fluctuation in norm and pathology.
Nadezhda J Japaridze; Vera G Okuneva; Mariam G Qsovreli; Arkadi G Surmava; Tamar G Lordkipanidze; Maia T Kiladze; Mzia G Zhvania
Related Documents :
15986887 - Role of trichome of pteris vittata l. in arsenic hyperaccumulation.
24957067 - Insights on the study of nafion nanoscale morphology by transmission electron microscopy.
4836387 - Identification of mast cells in the scanning electron microscope by means of x-ray spec...
524397 - Micro-buffy coats of whole blood: a method for the electron microscopic study of mononu...
18524607 - Measurements of activation cross-sections for the 96ru(n,d*)95gtc reaction for neutrons...
25278507 - Observation of majorana fermions in ferromagnetic atomic chains on a superconductor.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-6
Journal Detail:
Title:  Micron (Oxford, England : 1993)     Volume:  -     ISSN:  1878-4291     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312850     Medline TA:  Micron     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
I. Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 0160 Tbilisi, Georgia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.
Next Document:  Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and found.