| Hypokalemic thyrotoxic periodic paralysis: clinical characteristics and predictors of recurrent paralytic attacks. | |
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MedLine Citation:
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PMID: 18410374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: To study the clinical characteristics of hypokalemic thyrotoxic periodic paralysis (hoTPP) and identify the predictors of recurrent paralytic attacks before achieving the euthyroid status. METHODS: We retrospectively analyzed 45 hoTPP patients who were admitted during the 7-year study period. RESULTS: A tendency towards male predominance was observed among the 45 patients (91.1%, 41/45). The mean onset age was 32.9 +/- 10.0 years (range: 16-54 years). No significant differences were observed in the onset age between male and female patients. Precipitating factors included rest/sleep at night, hot weather, upper respiratory tract infections (URIs), and excessive physical activities. Atypical weakness was observed in nine (20%, 9/45) patients. One patient initially diagnosed with sporadic periodic paralysis eventually developed hoTPP. DISCUSSION: In provocative tests, hypokalemia was not a consistent finding during paralytic attacks. Before achieving the euthyroid status, the rate of recurrent attacks was as high as 62.2%, and peaked in the first 3 months after hoTPP was diagnosed. Patients with URIs exhibited a higher incidence of recurrent paralytic attacks than those without (odds ratio = 13.00; 95% confidence interval = 1.08-156.08; P = 0.04). |
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Authors:
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M-J Hsieh; R-K Lyu; W-N Chang; K-H Chang; C-M Chen; H-S Chang; Y-R Wu; S-T Chen; L-S Ro |
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Publication Detail:
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Type: Journal Article Date: 2008-04-10 |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 15 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2008-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 559-64 Citation Subset: IM |
Affiliation:
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Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Female Humans Hypokalemic Periodic Paralysis / epidemiology, physiopathology* Male Retrospective Studies Risk Factors Sex Factors Thyroid Diseases / epidemiology, physiopathology* |
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