Document Detail

Hypokalemic rhabdomyolysis in a child due to amphotericin B therapy.
MedLine Citation:
PMID:  16906399     Owner:  NLM     Status:  MEDLINE    
Hypokalemia can result in life-threatening complications if not treated appropriately. Although hypokalemia is a frequent adverse effect of amphotericin B therapy, there are no reports in the pediatric literature on hypokalemia-associated rhabdomyolysis induced by this drug. A ten-year-old boy with a history of one week amphotericin B treatment was admitted with weakness of the lower extremities, inability to walk and calf pain. Laboratory tests showed a serum potassium of 1.7 mEq/L and a serum creatinine phosphokinase of 3937 U/L plus myoglobulinuria. Following fluid expansion and intravenous potassium replacement, the patient progressed to achieve full regression of muscular weakness after one week. This report highlights hypokalemia as a rare cause of rhabdomyolysis. Patients on amphotericin B should be checked for this rare yet potentially life-threatening complication.
Paulo Sérgio Lucas da Silva; Simone Brasil de Oliveira Iglesias; Jaques Waisberg
Related Documents :
9470329 - Maintenance therapy with itraconazole after treatment of cryptococcal meningitis in the...
10397379 - Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute fa...
18544199 - Outcome of treatment of mdr-tb patients with standardised regimens, iran, 2002-2006.
19357749 - Worsening and unmasking of tuberculosis in hiv-1 infected patients after initiating hig...
367239 - Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind s...
2583909 - Dermal leishmaniasis and rifampicin.
10524919 - Percutaneous management of renal calculi: experience with percutaneous nephrolithotomy ...
23132539 - Cervical myelopathy in patients with athetoid cerebral palsy.
21933399 - Changes of monocyte human leukocyte antigen-dr expression as a reliable predictor of mo...
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-08-12
Journal Detail:
Title:  European journal of pediatrics     Volume:  166     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
Pediatric Intensive Care Unit, Department of Pediatrics, Hospital do Servidor Público Municipal, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphotericin B / adverse effects*,  therapeutic use
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Follow-Up Studies
Hypokalemia / chemically induced*,  complications,  diagnosis
Rhabdomyolysis / chemically induced*,  complications,  diagnosis
Surgical Wound Infection / drug therapy
Reg. No./Substance:
0/Anti-Bacterial Agents; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Duration of isolation of children with influenza A treated with oseltamivir.
Next Document:  Transoral osteosynthesis of condylar neck fractures using a three-dimensional plate