Document Detail

Hypokalemic rhabdomyolysis in a child due to amphotericin B therapy.
MedLine Citation:
PMID:  16906399     Owner:  NLM     Status:  MEDLINE    
Hypokalemia can result in life-threatening complications if not treated appropriately. Although hypokalemia is a frequent adverse effect of amphotericin B therapy, there are no reports in the pediatric literature on hypokalemia-associated rhabdomyolysis induced by this drug. A ten-year-old boy with a history of one week amphotericin B treatment was admitted with weakness of the lower extremities, inability to walk and calf pain. Laboratory tests showed a serum potassium of 1.7 mEq/L and a serum creatinine phosphokinase of 3937 U/L plus myoglobulinuria. Following fluid expansion and intravenous potassium replacement, the patient progressed to achieve full regression of muscular weakness after one week. This report highlights hypokalemia as a rare cause of rhabdomyolysis. Patients on amphotericin B should be checked for this rare yet potentially life-threatening complication.
Paulo Sérgio Lucas da Silva; Simone Brasil de Oliveira Iglesias; Jaques Waisberg
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-08-12
Journal Detail:
Title:  European journal of pediatrics     Volume:  166     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
Pediatric Intensive Care Unit, Department of Pediatrics, Hospital do Servidor Público Municipal, São Paulo, Brazil.
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MeSH Terms
Amphotericin B / adverse effects*,  therapeutic use
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Follow-Up Studies
Hypokalemia / chemically induced*,  complications,  diagnosis
Rhabdomyolysis / chemically induced*,  complications,  diagnosis
Surgical Wound Infection / drug therapy
Reg. No./Substance:
0/Anti-Bacterial Agents; 1397-89-3/Amphotericin B

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