Document Detail

The hypointense liver lesion on T2-weighted MR images and what it means.
MedLine Citation:
PMID:  19901085     Owner:  NLM     Status:  MEDLINE    
The vast majority of focal liver lesions are hyperintense on T2-weighted magnetic resonance (MR) images. Rarely, however, hepatic nodules may appear totally or partially hypointense on those images. Causes for this uncommon appearance include deposition of iron, calcium, or copper and are related to the presence of blood degradation products, macromolecules, coagulative necrosis, and other conditions. Although rare, low signal intensity relative to surrounding liver on T2-weighted images may be seen in a wide spectrum of lesions. Examples include cases of focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, metastases, leiomyoma, siderotic or dysplastic nodules, nodules in Wilson disease, granuloma, and hydatid cyst. On fat-suppressed T2-weighted images, nodules with a lipomatous component, such as lipoma, angiomyolipoma, hepatocellular adenoma, and hepatocellular carcinoma may also appear partially or totally hypointense. The conjunction of other MR imaging findings and their integration in the clinical setting may allow a correct diagnosis in a considerable proportion of cases. The cause for T2-weighted hypointensity may not be, however, always recognized, and only pathologic correlation may provide the answer. The aims of this work are to discuss the causes and mechanisms of hypointensity of liver lesions on T2-weighted images and proposing an algorithm for classification that may be useful as a quick reminder for the interested reader.
Luís Curvo-Semedo; Jorge B Brito; Miguel F Seco; João F Costa; Cristina B Marques; Filipe Caseiro-Alves
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Publication Detail:
Type:  Journal Article     Date:  2009-11-09
Journal Detail:
Title:  Radiographics : a review publication of the Radiological Society of North America, Inc     Volume:  30     ISSN:  1527-1323     ISO Abbreviation:  Radiographics     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-04-05     Revised Date:  2010-11-22    
Medline Journal Info:
Nlm Unique ID:  8302501     Medline TA:  Radiographics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e38     Citation Subset:  IM    
Department of Radiology, Coimbra University Hospital, Praceta Mota Pinto/Av. Bissaya Barreto, Coimbra, Portugal.
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MeSH Terms
Diagnosis, Differential
Image Enhancement / methods*
Liver / pathology*
Liver Diseases / diagnosis*
Magnetic Resonance Imaging / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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