Document Detail

Hypohidrosis and hyperthermia during topiramate treatment in children.
MedLine Citation:
PMID:  23427516     Owner:  NLM     Status:  MEDLINE    
Topiramate is one of the newer generation antiepileptic drugs with a beneficial clinical effect on various seizure types. In this study, we present the clinical findings of hypohidrosis and hyperthermia with topiramate in pediatric patients. The data were collected retrospectively on 173 patients diagnosed as epilepsy on topiramate treatment, and hypohidrosis-related symptoms induced by topiramate were found in 22 patients. Their mean age was 64.45 +/- 56.63 months. The mean duration of topiramate treatment was 7.09 +/- 2.46 months, and the mean dose was 5.37 +/- 1.75 mg/kg/day. All of the patients complained of hypohidrosis and hyperthermia. Six (27.2%) of them had facial flushing, 4 (18.1%) had heat sensation and only 1 (4.5%) had lethargy. Hypohidrosis-related symptoms resolved after discontinuation of the medication. In conclusion, children treated with topiramate should be cautioned regarding these potential adverse effects and advised to avoid its use during the hot summer season.
Faruk Incecik; M Ozlem Hergüner; Sakir Altunbaşak
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  54     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-02     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  515-8     Citation Subset:  IM    
Department of Pediatric Neurology, Cukurova University Faculty of Medicine, Adana, Turkey.
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MeSH Terms
Anticonvulsants / adverse effects,  therapeutic use
Child, Preschool
Dose-Response Relationship, Drug
Fever / chemically induced*,  epidemiology
Follow-Up Studies
Fructose / adverse effects,  analogs & derivatives*,  therapeutic use
Hypohidrosis / chemically induced*,  epidemiology
Retrospective Studies
Risk Factors
Seizures / drug therapy*
Turkey / epidemiology
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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