Document Detail

Hypogonadotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron overload presenting with infertility.
MedLine Citation:
PMID:  22035015     Owner:  NLM     Status:  Publisher    
Improved care of β-thalassemia major (β-TM) patients has brought with it new challenges for the patient to have a family. We report our 15-year experience with 30 couples with 28 pregnancies following artificial reproductive techniques (ART). Sixty percent of females had hypogonadotrophic hypogonadism (HH) with diminished ovarian reserve and responded favorably to gonadotrophins with 80% success rate within three cycles. Pulsatile gonadotrophin-releasing hormone (GnRH) infusion was used in one and clomiphene in another patient which resulted in successful pregnancies. Males responded less favorably than females. Gonadotrophins were used in 14 pulsatile HH patients for 6-24 months with variable outcomes. Although successful paternity did not occur, successful spermatogenesis with oligoasthenospermia occurred in six men. Two had in vitro fertilization (IVF) and intracytoplasmic injections (ICSI), which resulted in healthy offspring. In conclusion, successful pregnancy and fertility are feasible in β-TM patients with diminished gonadal reserves. Better outcome is expected in females than males. We report the first two cases of paternity following IVF and ICSI in β-TM patients with HH.
Rekha Bajoria; Ratna Chatterjee
Related Documents :
18217325 - Influence of gestational period on sexual behavior.
16466355 - Fathers' perspectives during pregnancy, postperinatal loss.
24047195 - The role of osmoregulation in the pathophysiology and management of severe ovarian hype...
22508575 - Maternal serum human chorionic gonadotropin and pregnancy-associated plasma protein-a i...
18771995 - Effect of a change in policy regarding the timing of prophylactic antibiotics on the ra...
6798875 - Maternal smoking causes fetal hypoxia: experimental evidence.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-28
Journal Detail:
Title:  Hemoglobin     Volume:  -     ISSN:  1532-432X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute For Women's Health, University College London (UCL) , London , UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Single nucleotide polymorphisms in the Melanocortin 1 Receptor gene are linked with lightness of fib...
Next Document:  Non-invasive muscle contraction assay to study rodent models of sarcopenia.